CRISPR-Cas系统是细菌抵御病毒入侵的关键适应性免疫机制，而噬菌体等可移动遗传元件则进化出多种“反CRISPR”蛋白来对抗这一防御。研究发现，噬菌体可利用一类特殊的RNA分子来干扰CRISPR-Cas系统（RacrIF1）。然而，RacrIF1 ...

A CRISPR system detects rare cancer mutations in blood with single-nucleotide precision, outperforming ddPCR through engineered RNA guides and isothermal amplification. (Nanowerk Spotlight) Hidden ...

But it turns out that CRISPR systems have more than one strategy in their toolkit. A mechanism originally discovered in bacteria, where it has operated as an adaptive immune system for eons, CRISPR is ...

Genetic disorders occur due to alterations in the primary genetic material—deoxyribonucleic acid (DNA)—of an organism. Transthyretin amyloidosis (ATTR) is a progressive disorder involving amyloid ...

It acts as a sort of molecular fumigator to battle phages and plasmids. CRISPR-Cas9 has long been likened to a kind of genetic scissors, thanks to its ability to snip out any desired section of DNA ...

Like the find-and-replace feature of a word processor, CRISPR-based engineering allows scientists to quickly and efficiently edit DNA sequences with base pair precision. Lauded as the great ...

Researchers from Japan have established a new in vivo genome-editing system, CRISPR–Cas3, as a promising therapeutic approach for ATTR Genetic disorders occur due to alterations in the primary genetic ...

(a) Utilizing HCR and CRISPR-Cas12a double amplification technique, a highly sensitive apta-HCR-CRISPR method was devised for the detection of TEV protein. (b) A novel CRISPR-Cas12a/Cas13a approach, ...

Add Yahoo as a preferred source to see more of our stories on Google. The idea that a single-celled bacterium can defend itself against viruses in a similar way as the 1.8-trillion-cell human immune ...

Microbiologist John van der Oost of Wageningen University & Research (WUR) has received an ERC Proof of Concept grant to further develop a promising CRISPR-based approach to cancer treatment. With ...