Muscle-derived branched-chain amino acids support thermogenesis in brown adipose tissue, thereby helping maintain body temperature during impaired muscle function or physiological stress.

Mutations that activate phosphorylation of certain Rab GTPases by LRRK2 have been linked to a subset of genetic cases of Parkinson’s disease, and PPM1M is one of the phosphatases responsible for ...

Researchers have identified a new genetic cause of hereditary optic atrophy—a condition that leads to gradual vision loss—by discovering a previously unknown mutation in the PPIB gene. T ...

Use of givinostat plus systemic corticosteroids for a mean of 560 days was associated with delays of 2-3 years in loss of key motor functions in patients with Duchenne muscular dystrophy (DMD), an ...

Researchers have understood for decades that some forms of deafness are inherited, yet until now, few of those genetic clues ...

Kidney function during the second trimester may be associated with adverse pregnancy outcomes for women with lupus, particularly for women with lupus nephritis, according to study findings published ...