高效筛选抗原肽的磁小体显示系统研究 在现代免疫学和疫苗开发领域，准确识别能够与主要组织相容性复合体II类分子（MHC II）结合的抗原性肽是至关重要的。MHC II分子作为细胞表面抗原呈递的关键蛋白，负责将病原体来源的肽段展示给T细胞，从而激活适应性 ...

MHC class II molecules are central to the adaptive immune response, serving as the means by which antigen-presenting cells, notably dendritic cells, display processed peptides to CD4+ T cells. This ...

本研究聚焦于微小病变型肾病（MCD）中T细胞异常激活与足细胞损伤之间的关联机制这一未解难题。研究人员围绕“足细胞来源外泌体（Pdo-Exos）是否及如何通过抗原呈递激活CD8+T细胞”这一主题展开研究，综合运用体外共培养、PAN诱导MCD小鼠模型及临床样本分析。

Recent analyses show that Omicron variants of SARS-CoV-2 more strongly suppress major histocompatibility complex class I expression than previous versions of the virus. Throughout the pandemic, the ...

Analysis of primary and acquired resistance to cetuximab from multiomic data in the New EPOC trial. This is an ASCO Meeting Abstract from the 2023 ASCO Annual Meeting I. This abstract does not include ...

Major histocompatibility complex class II (MHC-II) molecules play a critical, yet historically overlooked, role in tumor immunity. This review synthesizes emerging mechanistic evidence showing that ...

Ignite Proteomics LLC, a subsidiary of IMAC Holdings, Inc., announced new findings that show MHC-II protein expression is a more reliable predictor of response to pembrolizumab (Keytruda®) than the ...

A new study published on the preprint server bioRxiv* analyzed the mechanisms by which two SARS-CoV-2 accessory proteins, ORF3a and ORF7a, can downregulate the expression of major histocompatibility ...

Major Histocompatibility Complex (MHC) molecules display antigens to T cells, immune cells that constantly check for infected or damaged cells. If T cells spot MHC molecules with foreign antigens or ...

A new study sheds light on why some patients with the most aggressive form of ovarian cancer respond better to treatment than others. Tumors positive for a molecule called MHC class II are linked to ...

A new study sheds light on why some patients with the most aggressive form of ovarian cancer respond better to treatment than others. Tumors positive for a molecule called MHC class II are linked to ...