本综述系统阐述了PI3K/AKT信号通路在代谢相关脂肪性肝病（MASLD）及其进展形式MASH发病机制中的核心作用，重点归纳了天然 ...

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本研究针对非小细胞肺癌（NSCLC）转移和复发难题，聚焦KLK5在失巢凋亡抵抗（AR）中的作用机制。通过构建AR-H1299细胞模型 ...

Prognostic value of hedgehog signaling in cervical carcinoma. Background: Although improvements in the treatment of ovarian cancer have increased the global prognosis, the metastatic disease is still ...

Evidence for Cure by Adjuvant Therapy in Colon Cancer: Observations Based on Individual Patient Data From 20,898 Patients on 18 Randomized Trials These results suggest that common genetic variations ...

Antioxidant-1 may promote HCC carcinogenesis through the activation of the c-Myb/PI3K/AKT pathway and the inhibition of copper accumulation and oxidative stress. Despite advancements in diagnostic and ...

Panelists discuss how mutations in the NF1 gene lead to loss of neurofibromin function, resulting in hyperactivation of the RAS/MAPK and PI3K/AKT/mTOR pathways, and how this molecular dysregulation ...