The usual methodology employed in analysis after a sequential clinical trial is based on orderings of the possible samples resulting from the design. However, this approach lacks flexibility for use ...

This is a preview. Log in through your library . Biometrika is primarily a journal of statistics in which emphasis is placed on papers containing original theoretical contributions of direct or ...

The number needed to treat, that is, the average number of patients a clinician needs to treat with a particular therapy to prevent one bad outcome,1 is a translation into clinical terms of the ...

To present a resampling approach to obtain confidence intervals (CIs) and the empirical distributions for the studentized regression residuals percentiles when used as cutoff points for overweight and ...

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