Determining aqueous compound solubility has become an essential tool in the early stages of the drug discovery process. Solubility of a compound is important in the Biopharmaceutics Classification ...

With both the comparative-molecular-field analysis (CoMFA) and the comparative-molecular-similarity-indices analysis (CoMSIA), the paper describes two five-component ...

The authors demonstrate how melt-extrusion and spray-drying methods can help to prepare solid dispersions of poorly soluble drugs using Eudragit polymers. The number of poorly soluble drugs continues ...