DNA is often described as the instruction manual for building the fundamental components of life. Proteins are helpers that ...

在我们的细胞核中，DNA虽然受到严密包裹与保护，但这种保护并非绝对。无论是正常代谢过程产生的副产物，还是外界的辐射和化学物质等压力，都可能对DNA造成损伤。细胞依赖一整套精密的DNA修复系统来应对这些威胁，一旦修复机制失效，积累的DNA损伤便会破坏细 ...

Researchers show that loss of the SPRTN enzyme lets DNA–protein crosslinks accumulate, leak DNA into the cytoplasm, activate ...

Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal ...

If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by ...

Unrepaired DNA-protein crosslinks (DPCs) – highly toxic tangles of protein and DNA – cause a process that leads to premature ...

New research from the Kind Group at the Hubrecht Institute sheds light on how cells repair damaged DNA. For the first time, the team has mapped the activity of repair proteins in individual human ...

DNA can sustain serious injuries called double strand breaks, in which both strands of the helix snap. These breaks are among the most dangerous forms of DNA damage and immediately trigger the cell's ...

A new study shows that cancer damages its own DNA by pushing key genes to work too hard. Researchers found that the most ...

Objectives Understanding the molecular changes in the preclinical synovium is crucial for identifying factors that drive ...