Ubiquitination of Proteins and Protein Degradation
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YouTubeHussain Biology
Ubiquitination of Proteins and Protein Degradation
Ubiquitination is an enzymatic post-translational modification in which a ubiquitin protein is attached to a substrate protein. This process most commonly binds the last amino acid of ubiquitin to a lysine residue on the substrate. The ubiquitination tags the protein for degradation via Proteosome Pathway.
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Structure of human ubiquitin activating enzyme E1 (Uba1, blue) in complex with ubiquitin (pink), 3D cartoon and Gaussian surface model, based on PDB 6dc6, black background
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