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Acute pain processing and pathway
1. Transduction Initiation of pain: Occurs at the site of injury from noxious insult. Chemical mediators: Released from damaged tissue (e.g., prostaglandins, glutamate, substance P, bradykinin, histamine). Neuron activation: Stimulates peripheral nerve fibers (A-delta for sharp pain (initial), C-fibers for dull pain (‘second’ pain ...
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